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The cause of MSI-Hin LS was initially described as being due to mutations in genes speci?c regions ofDNA on Chromosomes 2p22-21 [ 32] and 3p22.3 [ 33]. For many older indi-viduals, driving may be their only means of maintainingcontact with their surrounding world; they may not havean intact social support group to which they can reach fortransportation assistance

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